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Serum Biomarkers of Myocardial Remodeling and Coronary Dysfunction in Early Stages of Hypertrophic Cardiomyopathy in the Young

I. Fernlund, Eva (author)
Linköpings universitet,Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnkardiologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Children cardiology,Lund University Research Groups,Skåne University Hospital,Linköping University Hospital,Lund Univ, Skane Univ Hosp, Pediat Heart Ctr, Lund, Sweden.; Linkoping Univ, Linkoping Univ Hosp, Dept Paediat, Linkoping, Sweden,Avdelningen för barns och kvinnors hälsa,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Lund University, Sweden
Gyllenhammar, T. (author)
Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital,Lund Univ, Univ Lund Hosp, Dept Clin Sci, Lund, Sweden,Lund University, Sweden
Jablonowski, R. (author)
Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital,Lund Univ, Univ Lund Hosp, Dept Clin Sci, Lund, Sweden,Lund University, Sweden
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Carlsson, M. (author)
Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Lund Univ, Univ Lund Hosp, Dept Clin Sci, Lund, Sweden,Lund University, Sweden
Larsson, Anders (author)
Uppsala universitet,Uppsala University,Biokemisk struktur och funktion,Uppsala University, Sweden
Ärnlöv, Johan (author)
Uppsala universitet,Karolinska Institutet,Uppsala University,Karolinska Institute,Kardiovaskulär epidemiologi,Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol, Care Sci & Soc, Huddinge, Sweden,Uppsala University, Sweden; Karolinska Institute, Sweden
Liuba, P. (author)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnkardiologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Children cardiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Pediat Heart Ctr, Lund, Sweden,Lund University, Sweden
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 (creator_code:org_t)
2017-03-30
2017
English 11 s.
In: Pediatric Cardiology. - : Springer Science and Business Media LLC. - 0172-0643 .- 1432-1971. ; 38:4, s. 853-863
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Hypertrophic cardiomyopathy (HCM) remains the leading cause of sudden cardiac death in the young. Early markers for HCM are important to identify individuals at risk. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis, and vascular endotheliopathy in the early stages of familial HCM in young patients. Twenty-three HCM patients, 16 HCM-risk individuals, and 66 controls (median 15 years) underwent echocardiography and serum analysis for cathepsin S, endostatin, myostatin, type I collagen degradation marker (ICTP), matrix metalloproteinase (MMP)-9, vascular endothelial growth factor receptor (VEGFR)-1, and vascular and intercellular adhesion molecules (VCAM, ICAM). In a subset of the population, global myocardial perfusion was performed by magnetic resonance imaging. Cathepsin S (p = 0.0009), endostatin (p < 0.0001), MMP-9 (p = 0.008), and VCAM (p = 0.04) were increased in the HCM group and correlated to left ventricular mass index and mitral E/e′ (p < 0.01). In the HCM-risk group, myostatin was decreased (p = 0.004), whereas ICAM was increased (p = 0.002). Global perfusion was decreased in the HCM group (p < 0.05) versus controls. Endostatin and mitral E/e′ correlated inversely to myocardial perfusion (p ≤ 0.05). This is the first study demonstrating adverse changes in biomarkers reflecting myocardial matrix remodeling, microfibrosis, and vascular endotheliopathy in early stage of hypertrophic cardiomyopathy in the young.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

Biomarkers
Early stage
Hypertrophic cardiomyopathy
Myocardium
Risk
Biomarkers

Publication and Content Type

art (subject category)
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